I recently upgraded to Vista Ultimate and also just started using DriveHQ.
I use it for work and home file management and found it very useful.
I have notice that Vista is not playing nice with Filemanager 3.8 as my device manager link is no longer accessible when DriveHQ is installed. I am only passing on this info incase others start using it with Vista. I am not sure if maybe it is the current release of if someone knows of of one of the older releases that worked with Vista. The device manager link works fine if DriveHQ filemanger is removed. I put it in when I need it and remove it if I want proper access to the device manager link.